publications

NAD+ supplements

NAD+ plays a key role in many activities in the body with aging decline. Studies show that NAD+ levels drop almost 50% once we reach middle age, which increases the risk of accelerated aging and the development or progression of age-related disorders. Keeping NAD+ levels elevated, especially in later life, may help to slow down aspects of the aging process and keep our cells and organs healthy with each passing year.

Scientists have known about NAD+ for more than 100 years, NAD+ enables cells to generate cellular energy from the food, activate enzymes including PARPs and sirtuins. NAD+ has been shown to increase cellular metabolism and energy production, maintain healthy mitochondria and promote cellular repair.

Literature

The NAD Precursor Nicotinamide N Riboside R Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

By: Canto, Carles; Houtkooper, Riekelt H.; Pirinen, Eija; Youn, Dou Y.; Oosterveer, Maaike H.; Cen, Yana; Fernandez-Marcos, Pablo J.;
Yamamoto, Hiroyasu; Andreux, Penelope A.; Cettour-Rose, Philippe; et al
Cell Metabolism (2012), 15(6), 838-847

Nicotinamide N riboside r is uniquely and orally bioavailable in mice and humans

By: Trammell, Samuel A. J.; Schmidt, Mark S.; Weidemann, Benjamin J.; Redpath, Philip; Jaksch, Frank; Dellinger, Ryan W.; Li,
Zhonggang; Abel, E. Dale; Migaud, Marie E.; Brenner, Charles
Nature Communications (2016), 7, 12948

Chronic nicotinamide n riboside r supplementation is well-tolerated and elevates NAD in healthy middle-aged and older adults

By: Martens, Christopher R. ; Denman, Blair A.; Mazzo, Melissa R.; Armstrong, Michael L.; Reisdorph, Nichole; McQueen, Matthew
B.; Chonchol, Michel; Seals, Douglas R.
Nature Communications (2018), 9(1), 1-11

Effective treatment of mitochondrial myopathy by nicotinamide n riboside r , a vitamin B3

By: Khan, Nahid A.; Auranen, Mari; Paetau, Ilse; Pirinen, Eija; Euro, Liliya; Forsstroem, Saara; Pasila, Lotta; Velagapudi, Vidya; Carroll,
Christopher J.; Auwerx, Johan; et al
EMBO Molecular Medicine (2014), 6(6), 721-731

Nicotinamide N Riboside R Augments the Aged Human Skeletal Muscle NAD Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures

By: Elhassan, Yasir S.; Kluckova, Katarina; Fletcher, Rachel S.; Schmidt, Mark S.; Garten, Antje; Doig, Craig L.; Cartwright, David M.;
Oakey, Lucy; Burley, Claire V.; Jenkinson, Ned; et al
Cell Reports (2019), 28(7), 1717-1728.e6

Nicotinamide N Riboside R Opposes Type 2 Diabetes and Neuropathy in Mice

By: Trammell, Samuel A. J.; Weidemann, Benjamin J.; Chadda, Ankita; Yorek, Matthew S.; Holmes, Amey; Coppey, Lawrence J.;
Obrosov, Alexander; Kardon, Randy H.; Yorek, Mark A.; Brenner, Charles
Scientific Reports (2016), 6, 26933

The NAD+ Precursor Nicotinamide N Riboside R Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson’s Disease

By: Schoendorf, David C.; Ivanyuk, Dina; Baden, Pascale; Sanchez-Martinez, Alvaro; De Cicco, Silvia; Yu, Cong; Giunta, Ivana; Schwarz,
Lukas K.; Di Napoli, Gabriele; Panagiotakopoulou, Vasiliki; et al
Cell Reports (2018), 23(10), 2976-2988

Nicotinamide N riboside r -the current state of research and therapeutic uses

By: Mehmel, Mario; Jovanovic, Nina; Spitz, Urs
Nutrients (2020), 12(6), 1616

Nicotinamide Riboside—The Current State of Research and Therapeutic Uses

Nicotinamide riboside (NR) has recently become one of the most studied nicotinamide adenine dinucleotide (NAD+) precursors, due to its numerous potential health benefits mediated

via elevated NAD+ content in the body.

Safety and Metabolism of Long-term Administration of NIAGEN ( Nicotinamide N Riboside R Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults

By: Conze, Dietrich; Brenner, Charles ; Kruger, Claire L.
Scientific Reports (2019), 9(1), 1-13

Nicotinamide N riboside r is a major NAD precursor vitamin in cow milk

By: Trammell, Samuel A. J.; Yu, Liping; Redpath, Philip; Migaud, Marie E.; Brenner, Charles
Journal of Nutrition (2016), 146(5), 957-963

Nicotinamide riboside, a form of vitamin B3, protects against excitotoxicity-induced axonal degeneration

By: Vaur, Pauline; Brugg, Bernard; Mericskay, Mathias; Li, Zhenlin; Schmidt, Mark S.; Vivien, Denis; Orset, Cyrille; Jacotot, Etienne;

Brenner, Charles; Duplus, Eric

FASEB Journal (2017), 31(12), 5440-5453